S.H. Madani; Gh. Naderi; S. Asgari; D. Khaksar; M. Talebalhoseini
Volume 22, Issue 2 , September 2006, , Pages 79-84
Abstract
The researches have shown that some plants extracts has protective effects on rats hepatocytes. Most plants have different phenol compounds that for eliciting of them solvents such as ethanol, ethyl acetate and water are used. These phenol compounds are able to neutralize free radicals by giving them ...
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The researches have shown that some plants extracts has protective effects on rats hepatocytes. Most plants have different phenol compounds that for eliciting of them solvents such as ethanol, ethyl acetate and water are used. These phenol compounds are able to neutralize free radicals by giving them electrons. Thioacetamide as a destructive toxin in hepatocytes is changed into S-oxide metabolic which is a dangerous free radical and can lead to Necrosis and Apoptosis of hepatocytes. For evaluation of hepatocytes damages on the treated rats by thioacetamide and also the study of the effects of protective phenol compounds of silymbum h. extract and hydro alcoholic, aqueous ginger extract, the value of serum transaminasis of GPT, GOT, billirubin, Alkalin phosphatase, Sodium and potassium has been determined. In this research, the male and female of wistar race rats have been used. Rats were divided into ten group of five, then thioacetamide with a dose of 50 mg/kg and the extracts with a dose of 100 mg/kg were both injected (I.P) in a sequence of three days. 48 hours after the last injection, blood was directly taken from heart and its serum was prepared. The above mentioned factors were measured and the results have shown that ginger hydro alcoholic and aqueous extract and Silybum h. extract would have a positive effect on hepatocytes of rats treateds by thioacetamide (P<0/05). A significant difference was not seen among the factors in the male and female rat. Comparatively, the results have determined that the protective effect of Silymbum h. extract was higher than the ginger aqueous extract and ginger aqueous extract higher than ginger hydro alcoholic extract. The protective effect of these extracts is due to the existence of polyphenolic substances in the plants, these substances have an antioxidant function.
